Compounds 1 and 4 were found to exhibit strong cytotoxic activity. Labisia pumila myrsinaceae, also known as kacip fatimah, is an herb that has been widely applied as a decoction in south east asian. Safety and efficacy of a labisia pumila var alata water extract on. Antiproliferative and proapoptotic effects of labisia pumila. This is a randomized, doubleblind, placebocontrolled study comparing the effects of a water extract of labisia pumila var. Wan ezumi et al female reproductive toxicity of labisia pumila var. Time and dosedependent effects of labisia pumila on bone. Alkenylresorcinols and cytotoxic activity of the constituents.
Labisia pumila is a traditional herb widely used as postpartum medication for centuries. There are three variants of labisia pumila, which are var. Pdf safety and efficacy of labisia pumila containing. Recently, there is a remarkable boom in the sales of labisia pumila kacip fatimah in the malaysian mar ket, as an extract of the plant is used to gain energy and libido as well as to treat many. Active, expires 20270303 application number us130,701 other versions us20070082069a1 en. Results from the study revealed that ethanol extract of l. Abstracta randomized complete block design was used to characterize the. Photosynthetic capacity, photochemical efficiency and. There are three known varieties of labisia pumila, which are locally known as kacip fatimah. Three different varieties of this species were identified and found in malaysia. The aim of this study is to evaluate interaction of genotype x environment between eight selected labisia pumila var. Pdf safety and efficacy of labisia pumila containing products. Standardization of herbal preparations is vital to. Applications in plant sciences rapidly publishes new and innovative tools and protocols in all areas of the plant sciences.
Primary, secondary metabolites, photosynthetic capacity. Production of planting stock from kacip fatimah labisia. It is one of the five herbal plants identified by the government as one of the national key economic areas to be developed for commercial purposes. Labisia pumila extracts did not alter the estrous cycle and general health of all. The loss of bone mass due to the increasing age in women is caused by the decline in ovarian function, known as osteoporosis. The results of a previous study showed uterotrophic ef. The reductive potential of labisia pumila extracts in all three varieties and the standards at a concentration of 400 gml were found to be in the descending order of vitamin c bht.
The genus labisia is in the family primulaceae in the major group angiosperms flowering plants. The first comprehensive phytochemical study on this medicinal plant. The purpose of the present study was to analyze the effects of l. Labisia pumila, locally known as kacip fatimah, is a forestfloor plant that has tremendous potential in the herbal industry. Micropropagation technique of kacip fatimah labisia pumila. Demethylbelamcandaquinone b isolated from labisia pumila. The present invention relates to a process for obtaining a labisia pumila water extract comprising the steps of. Antifungal, antiinflammatory and cytotoxicity activities of three. Effects of labisia pumila var alata extracts on the lipid. Labisia pumila is a traditional medicinal plant which has wide therapeutic application including induction of labor and treatment of dysentery, dysmenorrhea and gonorrhea.
Labisia pumila has the potential to be used as an alternative treatment for postmenopausal osteoporosis. Pdf fractionation of labisia pumila using solidphase. Development of techniques for in vitro seed germination, callus induction and plant regeneration were successfully achieved by manipulation of plant growth factors such as basal medium, carbon source and plant growth regulator. Research article open access labisia pumila regulates bone. Evaluation of the female reproductive toxicity of aqueous. Myrsinaceae is a small understory shrub that is widely distributed in the tropical forests of malaysia, indonesia, thailand, the philippines, and myanmar sunarno, 2005.
Abandoned application number us12722,621 inventor mashitah mohd. Pdf flowability properties of labisia pumila herbal powder. An extensive study was conducted in a postmenopausal osteoporosis rat model using several lp doses and duration of treatments to determine if antioxidative mechanisms were involved in its bone protective. Micropropagation technique was established for labisia pumila bl. Effect of labisia pumila var alata consumption on the. Us9358260b2 optimized extraction process for obtaining. Pdf labisia pumila is traditionally used by malay woman to maintain healthy female reproductive function and as postpartum. It is a small subherbaceous perennial with creeping stems growing from 30 to 40 cm in height. Bioactive phytochemicals and skin collagen synthesis promoting herb. Menopausal symptoms were assessed at baseline and at 6 months. Keywords chlorophyll fluorescence a kacip fatimah a. In addition, the constituents of this plant have been reported to possess anticancer, antioxidant, and antiinflammatory properties. Pdf the potential of labisia pumila as an alternative.
Pdf chemical constituents of labisia pumila kacip fatimah. Pdf declining levels of estrogen in postmenopausal women has been shown to trigger and increase a womans risk of contracting various diseases, one of. Standardization and preliminary antiangiogenic study of. Chemical constituents of labisia pumila kacip fatimah. Labisia pumila var alata, locally known kacip fatimah, is a traditional herb used by malay women to induce and facilitate childbirth as well as to.
Labisia pumila kacip fatimah is a medicinal plant enriches with functional. Labisia pumila, locally known as kacip fatimah, is the queen of the herbs in malaysia. Structures were determined based on spectrometry and chemical reaction. Labisia herb fights candida and aids womens health.
In malaysia, it is known locally as kacip fatimah and the extract can simply be prepared by boil. Wo2016093692a1 standardised extract of labisia pumila for. Antiinflammatory effects of labisia pumila blume f. Evaluation of drug interaction potential of labisia pumila. Effects of labisia pumila var alata extracts on the lipid profile.
This pdf is available for free download from a site hosted. Pdf abstract labisia pumila myrsinaceae, also called kacip fatimah, is a. Thus, ethanol extract was selected to be further separated by using the. See status, confidence level, source for definitions. Evaluation of the female reproductive toxicity of aqueous extract of. Eight varieties are recognized sunarno, 2005, of which l. Jan 24, 20 labisia pumila, locally known as kacip fatimah, is a forestfloor plant that has tremendous potential in the herbal industry. The antiinflammatory, phytoestrogenic, and antioxidative. It is a genus of small woody and leafy plants of the myrsinaceae family that can widely be found in the tropical forest of south east asian countries.
However, there are no studies identifying the chemical constituents of kf responsible for cyp inhibition. Lp is found mainly in the lowland and hillforests of peninsular malaysia at an altitude between 300. Myrsinaceae, an important and potential medicinal herb species in malaysia. Labisia pumila extract regulates body weight and adipokines. The structures of two extracts of flavone, obtained from the stem l40 and leaf s40 of labisia pumila lp, were identified through uhplc.
Download fulltext pdf download fulltext pdf flowability properties of labisia pumila herbal powder article pdf available december 2014 with 147 reads. In earlier studies using postmenopausal model, lpva was able to reverse the ovariectomyinduced changes in biochemical markers, bone calcium, bone histomorphometric parameters and biomechanical strength. Labisia pumila kacip fatimah is a popular herb in malaysia that has been traditionally used in a number of womens health applications such as to improve libido, relieve postmenopausal symptoms, and to facilitate or hasten delivery in childbirth. Download fullsize image highlights nineteen compounds 119 were isolated from labisia pumila. Numerous studies have evaluated the benefits of labisia pumila, but not investigated the opgrankl system. A dry powder form of lpva extract is desired for is desirable owing to its long shelflife besides easier handling during storage and transportation. This pdf is available for free download from a site hosted by medknow publications. Us20100311180a1 process for preparation of labisia pumila. Us7879368b2 process for preparation of labisia pumila.
Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed. There is provided an extract of labisia pumila that comprises. The interaction of the active compounds of labisia pumila on. There were 29 patients treated with labisia pumila and 34 patients in the placebo group. Lp or more commonly known as kacip fatimah in malaysia has received much attention due to its estrogenic effects, including its role in the. Chemical composition, antioxidant and anticancer potential of. Labisia pumila is a popular herb known to contain highvalue metabolic compounds that are able to scavenge free radicals associated with chronic diseases e.
All in all, it is the antiinflammatory, phytoestrogenic, and antioxidative properties of lp that make it an effective natural medicine in treatment and prevention of osteoporosis. There are four known varieties of labisia pumila found in malaysia but only three of them are widely used by the locals, which are recognized as labisia pumila var. Labisia pumila extract regulates body weight and adipokines in. Development of microsatellites in labisia pumila myrsinaceae. It is a small, woody and leafy plant with leaves of 20 cm 7. Pdf potential role of labisia pumila in the prevention and. Labisia pumila is a traditional medicinal plant which has wide therapeutic application including induction of labor and treatment of dysentery,dysmenorrhea and gonorrhea. The present study was to determine the anticancer potential of labisia pumila in in vitro models. As part of our phytochemical studies on medicinal plants, several constituents have been isolated from the roots of l. The objective of this research was to analyze the interaction of the active ingredients in labisia pumila kaempferol, rutin, apigenin, caffeic acid, pyrogallol and gallic acid against rankranklopg system in context of osteoporosis. Antifungal, antiinflammatory and cytotoxicity activities of. Effects of labisia pumila on bone turnover markers and opg. Thermal degradation kinetics of labisia pumilas polyphenols.
Labisia pumila regulates bonerelated genes expressions in. This article is from international journal of molecular sciences, volume. Labisia pumila lpva or kacip fatimah is a popular supplement in the malaysian functional food and beverage market. Ade chandra, iwansyah 2011 studies of watersoluble extract of labisia pumila var alata of selected geographic origins. These research indicated that elicitation of whole plants labisia pumila var. Standardization of herbal preparations is vital to maintain quality, efficacy and safety. Studies of watersoluble extract of labisia pumila var.
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